After battling with Stephanie Pratt in previous episodes and on Twitter, Lucy accused her boyfriend James Dunmore of lying to her face and ruining her birthday.And a great many rival companies sought to capitalise on that reputation by marking their own wares with a mark similar to the Chelsea anchor mark.
She hosted the late-night talk show Chelsea Lately on the E!network from 2007 to 2014, and released a documentary series, Chelsea Does, on Netflix in January 2016. Other shows on which Handler has appeared include Weekends at the D.L., The Bernie Mac Show, My Wife and Kids, and The Practice. and Scarborough Country, as well as a correspondent on The Tonight Show.She hosted the first episode of the reality TV show On the Lot, but quit before the second episode aired, saying later that she left, "Because I smelled the disaster happening before it did." The show, produced by Steven Spielberg and Mark Burnett, was a competition for aspiring filmmakers vying for a chance at stardom. Handler was replaced by former Robin & Company entertainment anchor, Adrianna Costa.In April 2006, Handler began hosting The Chelsea Handler Show on E! In 2007, Handler performed with Comedy Central's Hour Stand-Up Comedy Tour across the United States.
Her stand-up comedy has also been televised on VH1's Love Lounge, Comedy Central's Premium Blend, and HBO's broadcast of the Aspen Comedy Festival.
She was a guest on Red Eye w/ Greg Gutfeld and The View, and she co-hosted The View on August 2, 2007, and September 5, 2008.
On August 18, 2010, it was announced that Handler would be the host of the 2010 MTV Video Music Awards.
The announcement was surprising to many, including MTV representatives, who claimed that the final decision was unexpected.
The event took place at the Nokia Theatre in Los Angeles on September 12, 2010. After more than 1,000 episodes, the final episode of Chelsea Lately aired on August 26, 2014.
In July 2007, Handler began starring on her own half-hour, late-night comedy series on E! The show proved to be a hit by averaging more than a half-million viewers since its premiere (much more than the average for a late night cable program) and having clips on You Tube with more than one million views. The show had a spinoff, the mockumentary After Lately, in which the various cast members, writers, crew, guests and even "hangers-on" of Chelsea Lately are shown bickering over trivial matters and competing for airtime on the show. Guest stars included: Reese Witherspoon, Jennifer Aniston, Jay Leno, Tori Spelling, Jenny Mc Carthy, Sharon Osbourne, Dave Grohl, Johnny Knoxville, and Jane Fonda.